I'm not sure that this is the right place to post this, but I couldn't find anywhere else that made sense.
I've searched for ways to make the user profile page more customizable and the truth is that there is very little that can be done using the current filters and hooks available.
So, to add more functionality to the user profile page, I came up with a (somewhat graceful) solution that mimics the new media editor page:
https://github.com/Flabadab/WordPress/blob/master/wp-admin/user-edit.php
By implementing the add_meta_box function on the user/profile edit page, all sections are completely customizable. I've also added 2 new action hooks that allow new fields to be added to the Name and Contact sections, without re-creating the entire meta box.