yudansha47c on "Pictures website"

Hello guys, I was wondering if it is possible to create a pictures website/blog using wordpress, and what plugings do you suggest ?
The idea of the blog is almost like http://www.memecenter.com in termes of navigation style, where I can browse images using next and previous buttons. While on the home page, will appear the lastest images uploaded.
I came up with an idea of putting every single image on posts, but I'm not sure if it the best way.
Also, is there a way to resize images in the homepage, but they keep their original size in the posts ?
Thank you in advance.
(English isn't my first language nor second :O)